Center for Bioinformatics at KU

As part of our public Seminar Series
http://bioinformatics.ku.edu/seminars

Apr 22, Tue 2008
11:00 am, MRB 200 Conference Room

Dr. Nick Grishin

Department of Biochemistry, University of Texas Southwestern Medical Center,

Protein Comparison: From New Methods to Unexpected Discoveries

Several new methods for remote homology inference between proteins, multiple alignment and structure similarity search will be discussed; and their applications to uncover unexpected and biologically meaningful connections between proteins will be demonstrated. In particular, a few examples of evolutionarily related proteins with very different spatial structure will be shown. The most extreme case is an all-beta barrel protein family with a few members folded as an alpha-helical hairpin.